To make things more specific, here's a screenshot from my project. I'm setting things up at 4:3 aspect ratio (for iPad). All I want to happen is for each of the four UI groups of controls (top-left, top-right, bottom-left, bottom-right) to stay in their corner when the aspect ratio changes. The message box (top-middle) should just stick to the top of the screen. I've tried a bunch of approaches though and they never behave properly - sometimes they end up moving right off screen, other times they don't move at all, etc.
Can anyone give me a couple of bullet points on the correct approach to take in this situation?
(http://www.coldfirekeep.com/wp-content/uploads/2012/09/cfk5.jpg)