Hi,
When you check the option "Offset anchors by position" on a panel, if the UIRoot is not at (0,0,0), the underlaying anchored widget is offset by the UIRoot position + the UIPanel position.
It should be only offsetted by the Panel position, I think.
In the screenshot, UIRoot is set to (0,10,0), UICamera to (0,0,0), UIPanel to (0,0,0) and the sprite is anchored to the top left corner of the Panel.