I've just started a new project with unity 4.5 using ngui 3.6.3. (I just updated to see if it would fix the problem, it didn't)
Currently while in play mode no buttons are responsive at all. Even in the example scenes that were included.
I even went as far as starting a fresh scene, making a new 2d ui and dragging a control - simple button prefab in to see if that would work and still no response to clicks or hovering.
I believe it to be a problem on NGUI's end, at least with the current version, because a project created in unity 4.4 with ngui 3.0.3f still was fully functional on the same machine.
Have I made some mistake? or is this a known problem and a fix is on it's way?