Pretty weird editor side error, not sure what can be the cause of this. It usually happens when the Editor loses focus, for example when you switch to your IDE or browser and come back later - at that point, there is a chance that UI widgets anchored to panels (for example, some top-level UIWidget holder attached to a top-right corner of it's panel) disappear from view of the UI camera and go into some extreme position like (-23223485, -6451236). This can only be fixed by reloading a scene or by pressing Apply on a prefab enclosing your UI hierarchy (that probably calls some method like OnEnable that reruns parts of UI code responsible for the issue).
I was very puzzled about the possible reasons behind this until one day I moved my main gameplay camera around an area where UI camera and elements are situated. I've left the UI layer rendered by the gameplay camera so that you'll see the situation clearly:
▲ WebM, click to viewAnd here is how things are supposed to work, properly anchored to UI camera:
▲ WebM, click to viewWhat might be causing this temporary use of a completely unrelated camera?
I'm using Unity 5.4.1f1, up to date version of NGUI. Nothing exotic about my setup, just one 2D UI in the scene, arranged into a traditional NGUI hiearchy (parent -> camera, root -> panels -> widgets).